tag:blogger.com,1999:blog-2186593343917545414.post1845213572023518936..comments2024-03-10T12:29:30.004-07:00Comments on pediatric neurology: Neuromyelitis opticaGalen Breningstall, MDhttp://www.blogger.com/profile/07170864203251456228noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-2186593343917545414.post-60868546172268576862016-01-10T23:03:27.565-08:002016-01-10T23:03:27.565-08:00Jeffery AR, Buncic JR. Pediatric Devic's neuro...Jeffery AR, Buncic JR. Pediatric Devic's neuromyelitis optica. J Pediatr Ophthalmol Strabismus. 1996 Sep-Oct;33(5):223-9.<br /><br />Abstract<br /><br /><br />PURPOSE: <br /><br />Neuromyelitis optica (Devic's disease) is a rare clinical syndrome of unilateral or bilateral optic neuritis (ON) and transverse myelitis (TM) occurring within an 8-week time interval. All reports mainly involve adults and describe a poor neurologic and ophthalmic clinical course without specific attention to their few pediatric cases. The purpose of this study was to develop a clinical profile in the pediatric population.<br /><br />METHODS: <br /><br />A retrospective chart review over 15 years revealed nine cases of neuromyelitis optica. A literature search was undertaken and all cases of pediatric neuromyelitis optica were tabulated and analyzed separately.<br /><br />RESULTS: <br /><br />The average age of onset was 7 years with a preceding viral prodrome in all patients. The optic neuritis was bilateral in eight of nine patients (89%). Visual loss ranged from 20/30 to light perception. Moderate anterior disc edema was seen in all 17 affected eyes. The clinical course was characterized by a rapid visual and neurologic recovery. The average follow up was 5.3 years, with five patients followed for 6 years or longer. None of the nine patients had any visual or neurologic recurrence or other significant subsequent illness. Visual system follow up showed 20/20 in each eye of all patients with mild optic atrophy, identified in 47% of eyes.<br /><br />CONCLUSIONS: <br /><br />Devic's neuromyelitis optica occurs in the pediatric population as a distinct clinical entity with an excellent prognosis for visual and systemic recovery and no future recurrence or long-term sequelae.Galen Breningstall, MDhttps://www.blogger.com/profile/07170864203251456228noreply@blogger.comtag:blogger.com,1999:blog-2186593343917545414.post-4896016622939215182016-01-10T23:00:32.711-08:002016-01-10T23:00:32.711-08:00Yuksel D, Senbil N, Yilmaz D, Yavuz Gurer YK. Devi...Yuksel D, Senbil N, Yilmaz D, Yavuz Gurer YK. Devic's neuromyelitis optica in an infant case. J Child Neurol. 2007 Sep;22(9):1143-6. <br /><br />Abstract<br /><br /><br />Devic's neuromyelitis optica was orginally described as an acute severe monophasic syndrome characterised by myelitis and optic neuritis. The mean age at onset was reported to be around 40 years, with a wide range. However, Devic's neuromyelitis optica has also been seen in children. Prognosis of the syndrome was poor, and no satisfactory treatment was known. This article reports a 23-month-old boy with acute myelitis and optic neuritis who was diagnosed with Devic's neuromyelitis optica. The response of the patient to therapy was poor, and he developed severe sequelae.Galen Breningstall, MDhttps://www.blogger.com/profile/07170864203251456228noreply@blogger.com