tag:blogger.com,1999:blog-2186593343917545414.post3240260493149450112..comments2024-03-10T12:29:30.004-07:00Comments on pediatric neurology: A genetics primerGalen Breningstall, MDhttp://www.blogger.com/profile/07170864203251456228noreply@blogger.comBlogger1125tag:blogger.com,1999:blog-2186593343917545414.post-15247111683319826892016-12-14T09:43:35.825-08:002016-12-14T09:43:35.825-08:00[From the link in the post. I believe this to be e...[From the link in the post. I believe this to be erroneous as applied to Jackson. T>G means that T has been changed to a G. With this transposition, and the transpositions that follow from it, the paragraph works.] To get a better idea of how this T>G could have arisen I spoke with cell biologist Carl Smythe, a professor in the Department of Biomedical Science at University of Sheffield, and also geneticist Shane McKee, clinical director of the Belfast Health & Social Care Trust.The 'T>G' doesn't necessarily mean that a G has been directly changed into a T in the gene. For example, such a transversion could arise as a consequence of a mutation from a C to A on the non-coding strand. G-A bases can pair quite well (as do some others, although normal pairing is A to T and G to C) without causing major structural issues between the coding (sense) and noncoding (antisense) strands. As a consequence of this, the A would have a T inserted in opposite strand in the next round of synthesis…Galen Breningstall, MDhttps://www.blogger.com/profile/07170864203251456228noreply@blogger.com