Tuesday, December 20, 2016

Arterial ischemic stroke and celiac disease

Balci O, Sezer T. The Prevalence of Celiac Disease in Children With Arterial
Ischemic Stroke. J Pediatr Hematol Oncol. 2017 Jan;39(1):46-49.

Abstract
OBJECTIVE:
The association between arterial ischemic stroke (AIS) and celiac disease (CD) has been described in only a few cases in adults and children. We aim to determine the prevalence of CD in children and adolescents with AIS.
STUDY DESIGN:
We investigated serum levels of tissue transglutaminase antibody immunoglobulin (Ig)A and total IgA from 76 children with AIS and in a healthy control group of 102 children. Study participants who were positive for tissue transglutaminase IgA antibodies underwent a duodenal biopsy.
RESULTS:
A total of 2 patients in the AIS group (2.26%) and 2 in the control group (1.96%) had positive serum tissue transglutaminase antibody (P=0.89; 95% confidence interval, -5.05 to 6.89). Duodenal biopsy confirmed CD in only 1 patient who had AIS.
CONCLUSIONS:
In the present study, children with acute arterial stroke did not exhibit a higher prevalence rate of CD compared with healthy controls. Therefore, the screening test for CD is not a necessary part of the management of AIS in children. However, cases of recurrent AIS could be examined for CD.

Courtesy of:  https://www.mdlinx.com/neurology/medical-news-article/2016/12/20/arterial-ischemic-stroke-celiac-disease-children/6983010/?category=latest&page_id=1

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