Wednesday, May 6, 2015

Ketogenic diet for epileptic encephalopathy with electrical status epilepticus during slow sleep

Between March 1, 1990 and April 1, 2013, 65 patients who met diagnostic criteria of ESES syndrome were seen at our department. Twelve of them were placed on the KD and followed for a minimum of 18 months...

The children had previously received a mean of 5.5 different AEDs and were on a mean of 3 AEDs when the diet was started. Eighteen months after initiating the diet, seven of the initial patients (58%) remained on the diet; one patient (8.3%) had become seizure free, one (8.3%) had a 75–99% decrease in seizures, two (16.6%) had a 50–74% decrease in seizures, and the remaining three children (24.9%) had a <50% decrease in seizures. In the patient who had become seizure free and in the one who had a 75–99% seizure decrease AEDs were reduced...

The KD is a well-tolerated treatment option for patients with ESES syndrome, not only for structural cases but also for those with an unknown etiology. The diet should be considered in the management of this syndrome.


Gabriela Reyes, Santiago Flesler, Marisa Armeno, Sebastian Fortini, Agustinho Ariela, Araceli Cresta, Graciella Mestre, Roberto Horacio Caraballo.  Ketogenic diet in patients with epileptic encephalopathy with electrical status epilepticus during slow sleep. Epilepsy Research , 2015, 113 , 126 - 131.

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