Thompson DF, Saluja HS. Prophylaxis of migraine headaches
with riboflavin: A systematic review. J Clin Pharm Ther. 2017 May 8. doi: 10.1111/jcpt.12548.
[Epub ahead of print]
Abstract
WHAT IS KNOWN AND OBJECTIVE:
Migraine headache is a relatively common, debilitating
condition that costs our healthcare system over 78 billion dollars per year.
Riboflavin has been advocated as a safe, effective prophylactic therapy for the
prevention of migraines. The purpose of this study was to provide a systematic
review of the current role of riboflavin in the prophylaxis of migraine
headache.
METHODS:
A MEDLINE literature search inclusive of the dates 1966-2016
was performed using the search terms: riboflavin and migraine disorders.
Excerpta Medica was searched from 1980 to 2016 using the search terms:
riboflavin and migraine. Additionally, Web of Science was searched using the
terms riboflavin and migraine inclusive of 1945-2016. Bibliographies of all
relevant papers were reviewed for additional citations. We utilized the PRISMA
guidelines to select English language, human, clinical trials of riboflavin as
a single entity or in combination, review articles, and supporting
pharmacokinetic and pharmacogenomic data assessing the efficacy and mechanism
of riboflavin therapy in the prophylactic treatment of migraine headache.
RESULTS AND DISCUSSION:
A total of 11 clinical trials reveal a mixed effect of
riboflavin in the prophylaxis of migraine headache. Five clinical trials show a
consistent positive therapeutic effect in adults; four clinical trials show a
mixed effect in paediatric and adolescent patients, and two clinical trials of
combination therapy have not shown benefit. Adverse reactions with riboflavin
have generally been mild.
WHAT IS NEW AND CONCLUSION:
Riboflavin is well tolerated, inexpensive and has
demonstrated efficacy in the reduction of adult patient's migraine headache
frequency. Additional data are needed, however, to resolve questions involving
pharmacokinetic issues and pharmacogenomic implications of therapy.
Courtesy of: https://www.mdlinx.com/neurology/medical-news-article/2017/05/11/migraine-headaches-riboflavin/7167598/?category=latest&page_id=4
Courtesy of: https://www.mdlinx.com/neurology/medical-news-article/2017/05/11/migraine-headaches-riboflavin/7167598/?category=latest&page_id=4
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