Tsai JD, Mou CH, Chang HY, Li TC, Tsai HJ, Wei CC. Trend of
subsequent epilepsy in children with recurrent febrile seizures: A
retrospective matched cohort study. Seizure. 2018 Aug 27;61:164-169. doi:10.1016/j.seizure.2018.08.019. [Epub ahead of print]
Abstract
PURPOSE:
Trends of epilepsy in children were correlated with febrile
seizure (FS) in a previous retrospective study. In the present study, the
authors obtained relevant data from a nationwide cohort database to investigate
trends in subsequent epilepsy in children with a history of recurrent FS.
METHODS:
A total of 10,210 children with FS comprised the cohort. The
diagnosis date was used as the index date. A comparison cohort was randomly
matched with each case based on age, sex, urbanization level, parents'
occupation, and index date. Cox proportional hazard regression was performed to
estimate the hazard ratio and confidence interval of FS-associated epilepsy.
RESULTS:
This retrospective cohort study included 7729 children with
FS and a comparison cohort of 30,916 children. The incidence of epilepsy was
11.4-fold higher in the FS cohort than in the comparison cohort (5.67 vs. 0.49
per 1000 person-years, respectively). Compared with the comparison cohort, the epilepsy
incidence rate ratio increased in children with admissions for FS, from 8.62 at
1 admission to 26.2 at ≥2 admissions (95% CI 6.80-10.9, and 19.78-34.8,
respectively; p for trend < 0.0001).
CONCLUSION:
FS may increase the risk for subsequent epilepsy in
children. Recurrent FS increased the cumulative incidence of epilepsy.
Courtesy of: https://www.mdlinx.com/journal-summaries/epilepsy-febrile-seizure-children-health-insurance/2018/08/29/7542974?spec=neurology
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