Monday, April 20, 2020

Seizures during treatment of childhood acute lymphoblastic leukemia

European Journal of Paediatric Neurology — Anastasopoulou S, Heyman M, Eriksson MA, et al. Seizures during treatment of childhood acute lymphoblastic leukemia: A population-based cohort study.  European Journal of Paediatric Neurology  April 20, 2020

Given that seizures are common in children with acute lymphoblastic leukemia (ALL), researchers analyzed the frequency, timing, etiology and risk factors of seizures in ALL individuals. Participants in the study were children aged 1–17.9 years at diagnosis of B-cell-precursor and T cell ALL who were treated according to the Nordic Society of Pediatric Haematology and Oncology ALL2008 protocol between 2008 and 2015. Data reported that seizures occurred in 81/1464 (5.5%) individuals. Results revealed that the cumulative incidence of seizures was 1.7% for one months and 5.3% for one year. Findings suggested that seizures are relatively common in ALL patients and most commonly occur in patients with posterior reversible encephalopathy syndrome, sinus venous thrombosis, or as an isolated symptom. Older children are at a higher risk of seizures.

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