Glennon JM, Weiss-Croft L, Harrison S, Cross JH, Boyd SG,
Baldeweg T.
Interictal epileptiform discharges have an independent
association with cognitive
impairment in children with lesional epilepsy. Epilepsia.
2016 Aug 9. doi:
10.1111/epi.13479. [Epub ahead of print]
Abstract
OBJECTIVES:
The relative contribution of interictal epileptiform
discharges (IEDs) to cognitive dysfunction in comparison with the underlying
brain pathology is not yet understood in children with lesional focal epilepsy.
METHODS:
The current study investigated the association of IEDs with
intellectual functioning in 103 children with medication-resistant focal
epilepsy. Hierarchical multiple regression analyses were used to determine the
independent contribution of IED features on intellectual functioning, after
controlling for effects of lesional pathology, epilepsy duration, and
medication. Exploratory analyses were conducted for language and memory scores
as well as academic skills available in a subset of participants.
RESULTS:
The results reveal that IEDs have a negative association
with IQ with independent, additive effects documented for frequent and
bilaterally distributed IEDs as well as discharge enhancement in sleep.
Left-lateralized IEDs had a prominent effect on verbal intelligence, in excess
of the influence of left-sided brain pathology. These effects extended to other
cognitive functions, most prominently for sleep-enhanced IEDs to be associated
with deficits in expressive and receptive language, reading, spelling and
numerical skills.
SIGNIFICANCE:
Overall, IED effects on cognition were of a magnitude
similar to lesional influences or drug effects (topiramate use). This study
demonstrates an association between IEDs and cognitive dysfunction, independent
of the underlying focal brain pathology.
http://www.mdlinx.com/neurology/medical-news-article/2016/08/10/cognitive-impairment-children-lesional-epilepsy/6813257/?category=sub-specialty&page_id=1&subspec_id=317
No comments:
Post a Comment