impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016 Mar 23.
doi: 10.1038/nature17427. [Epub ahead of print]
In their research on what they called a “leaky thalamus,” the scientists looked at what happens when a specific gene, Ptchd1, is deleted to genetically alter mice. The scientists found that Ptchd1 plays a role in modulating the amount of SK (small conductance calcium-dependent potassium currents) that help the thalamus communicate with other parts of the brain and inhibit inattention and hyperactivity
Mice without Ptchd1 made three times as many concentration errors in concentration tests as unaltered mice and had difficulties screening out distractions, the study said. These mice also were insensitive to treatment with stimulants, the study added, which suggested that the ADHD in the people who don’t respond to stimulants may have a disorder with a different origin. The authors noted that “ADHD symptoms are frequently observed in patients with Ptchd1 mutations.”