Friday, October 9, 2015

My endocannabinoids are kicking in at last!

We’ve probably all heard someone exclaim, “Ah, my endorphins are kicking in!” at the end of a good run. Endorphins are famous for supposedly producing “runner’s high,” that fleeting sense of calm and euphoria that engulfs many of us after a satisfying workout.
But in fact, endorphins may be unfairly hogging the credit for making workouts enjoyable, according to an enlightening new experiment with animals. The findings suggest that endorphins have little to do with runner’s high. Instead, that euphoric feeling may be the product of a completely different but oddly familiar substance — the body’s own endocannabinoids, the chemicals that, like the cannabinoids in marijuana, lighten mood...
Endorphins first became a household word in the 1980s, when researchers found that blood levels increased after prolonged exercise. This finding made sense. Exercise can cause discomfort or pain, and endorphins are the body’s self-produced opiates, with pain-relieving properties much like morphine.
From that discovery, it was a short step to believing that endorphins must also produce the pleasurable mental sensations that many people feel after exercise.
But there is a substantial problem with that idea, and it involves the substantialness of endorphins. They are large molecules, too big to pass through the blood-brain barrier. They might staunch pain in the muscles, but they wouldn’t have effects directly inside the brain, where any high would originate.
So for the past decade or so, scientists have been looking for other substances that might be involved in making exercisers feel high, which led them, perhaps unsurprisingly, to endocannabinoids.
Endocannabinoids are, essentially, internally produced marijuana, or cannabis. Cannabis contains cannabinoid molecules, which are small enough to cross the blood-brain barrier and attach there to receptors, producing a floaty, hey-dude high.
In recent years, scientists have found that exercise raises the levels of endocannabinoids in the bloodstreams of people and animals, making these molecules good candidates to underlie the runner’s high.
But few studies have directly compared the effects of endorphins and endocannabinoids to determine which really makes exercise mildly intoxicating...
But when the researchers used drugs to block the workings of some of the animals’ endocannabinoid system, so that receptors in the animals’ brains couldn’t take up the molecules, their post-run cool disappeared. The animals proved to be as anxious then after running as they had been before and very sensitive to pain.
Without a working endocannabinoid system, they developed no runner’s high.
However, when the researchers similarly blocked the animals’ response to endorphins, while leaving their endocannabinoid system unchanged, the mice enjoyed all of the soothing effects of running. They were calmer in their cages afterward and seemed to experience less sensitivity to pain...
More broadly encouraging, though, the results should remind us that, like mice, we were built through evolution to be in motion. Our ancestors ran to avoid danger and hunt food. For them, “reduced sensations of pain and less anxiety through long-distance running would have been a benefit,” says Johannes Fuss, now a professor at the University of Hamburg, who led the new study.
To survive as a species, we seem to have needed to run, and nature obligingly found ways to make this strenuous movement pleasurable by providing us with a runner’s high.
So the subtle upshot of the new study may be that we should run. And if we don’t feel a high, perhaps try running more, until eventually a gentle euphoria may settle in and we can turn to our running companion and say, “Ah, my endocannabinoids are kicking in at last!”
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1 comment:

  1. Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P. A runner's
    high depends on cannabinoid receptors in mice. Proc Natl Acad Sci U S A. 2015 Oct 5. pii: 201514996. [Epub ahead of print]


    Exercise is rewarding, and long-distance runners have described a runner's high as a sudden pleasant feeling of euphoria, anxiolysis, sedation, and analgesia. A popular belief has been that endogenous endorphins mediate these beneficial effects. However, running exercise increases blood levels of both β-endorphin (an opioid) and anandamide (an endocannabinoid). Using a combination of pharmacologic, molecular genetic, and behavioral studies in mice, we demonstrate that cannabinoid receptors mediate acute anxiolysis and analgesia after running. We show that anxiolysis depends on intact cannabinoid receptor 1 (CB1) receptors on forebrain GABAergic neurons and pain reduction on activation of peripheral CB1 and CB2 receptors. We thus demonstrate that the endocannabinoid system is crucial for two main aspects of a runner's high. Sedation, in contrast, was not influenced by cannabinoid or opioid receptor blockage, and euphoria cannot be studied in mouse models.