Factors associated with occurrence and outcome of super-refractory status epilepticus

Dominik Madžar, Ruben U. Knappe, Carloline Reindl, Antje Giede-Jeppe, Maximilian I. Sprügel, Vanessa Beuscher, Stephanie Gollwitzer, Hajo M. Hamer and Hagen B. Huttner.  Factors associated with occurrence and outcome of super-refractory status epilepticus. Seizure: European Journal of Epilepsy.  In press.

Highlights

• Our findings indicate a role of acute symptomatic etiologies in SRSE development.

• In-hospital mortality in SRSE depends on age and premorbid functional status.

• Functional outcome in survivors is determined by seizure duration

Abstract

Purpose

Super-refractory status epilepticus (SRSE) represents a challenging medical condition with high morbidity and mortality. In this study, we aimed to establish variables related to SRSE development and outcome.

Methods

We retrospectively screened our databases for refractory SE (RSE) and SRSE episodes between January 2001 and January 2015. Baseline demographics, SE characteristics, and variables reflecting the clinical course were compared in order to identify factors independently associated with SRSE occurrence. Within the SRSE cohort, predictors of in-hospital mortality as well as good functional outcome in survivors to discharge were established through univariate and multivariable analyses.

Results

A total of 131 episodes were included, among those 46 (35.1%) meeting the criteria of SRSE. Comparison of RSE and SRSE episodes revealed a lower premorbid mRS score (odds ratio (OR) per mRS point, 0.769; p = 0.039) and non-convulsive SE (NCSE) in coma (OR, 4.216; p = 0.008) as independent predictors of SRSE. SRSE in-hospital mortality was associated with age (OR, 1.091 per increasing year; p = 0.020) and worse premorbid functional status (OR, 1.938 per mRS point; p = 0.044). Good functional outcome in survivors was independently related to shorter SRSE duration (OR, 0.714 per day; p = 0.038).

Conclusion

Better premorbid functional status and NCSE in coma as worst seizure type indicate a role of acute underlying etiologies in the development of SRSE. In-hospital mortality in SRSE is determined by nonmodifiable factors, while functional outcome in survivors depends on seizure duration underscoring the need of achieving rapid seizure termination.