Oxcarbazepine in children

Geng H, et al.  Efficacy and safety of oxcarbazepine in the treatment of children with epilepsy: A meta-analysis of randomized controlled trials.  Neuropsychiatric Disease and Treatment, 03/07/2017

Abstract

Background: To assess the efficacy and safety of oxcarbazepine (OXC) in the treatment of children with epilepsy.

Methods: Randomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Cochrane Library, Scopus, SinoMed (Chinese BioMedical Literature Service System, China), and Chinese National Knowledge Infrastructure (China) database were systematically reviewed. Eligible studies were those that compared the efficacy and safety of OXC with other antiepileptic drugs in epilepsy. Risk ratio (RR) with 95% confidence intervals (95% CIs) was calculated using fixed-effects or random-effects model.

Results: Eleven RCTs with a total of 1,241 patients met the inclusion criteria and were included in this meta-analysis. Compared with other antiepileptic drugs (sodium valproate, levetiracetam, phenytoin, and placebo), OXC was associated with similar seizure-free rate (RR =1.06, 95% CI: 0.94, 1.20; P=0.366) and percentage reduction from baseline in seizure frequency (for ≥75% reduction: RR =1.15, 95% CI: 0.88, 1.49; P=0.310; for 50%–75% reduction: RR =1.12, 95% CI: 0.90, 1.39; P=0.301; for <50% reduction: RR =0.79, 95% CI: 0.56, 1.12; P=0.179). Moreover, patients treated with OXC had a comparable incidence of adverse events compared with those treated with other antiepileptic drugs (RR =1.01, 95% CI: 0.92, 1.11; P=0.760).

Conclusion: OXC showed similar effects and safety as other antiepileptic drugs in the treatment of children with epilepsy. Further well-conducted, large-scale RCTs are needed to validate these findings.

https://www.dovepress.com/efficacy-and-safety-of-oxcarbazepine-in-the-treatment-of-children-with-peer-reviewed-article-NDT
_____________________________________________________________________________

This meta–analysis aims to evaluate the efficacy and safety of oxcarbazepine (OXC) in the treatment of children with epilepsy. In the treatment of children with epilepsy, OXC showed similar effects and safety of other antiepileptic drugs.

Methods

The researchers systematically reviewed randomized controlled trials (RCTs) published in PubMed, Embase, Web of Science, Cochrane Library, Scopus, SinoMed (Chinese BioMedical Literature Service System, China), and Chinese National Knowledge Infrastructure (China) database.

Eligible studies were those that compared the efficacy and safety of OXC with other antiepileptic drugs in epilepsy.

Using fixed-effects or random-effects model, risk ratio (RR) with 95% confidence intervals (95% CIs) was calculated.

Results

In this meta-analysis, 11 RCTs with a total of 1,241 patients met the inclusion criteria and were included.

OXC was associated with similar seizure-free rate (RR =1.06, 95% CI: 0.94, 1.20; P=0.366) and percentage reduction from baseline in seizure frequency (for ≥75% reduction: RR =1.15, 95% CI: 0.88, 1.49; P=0.310; for 50%–75% reduction: RR =1.12, 95% CI: 0.90, 1.39; P=0.301; for <50% reduction: RR =0.79, 95% CI: 0.56, 1.12; P=0.179) compared with other antiepileptic drugs (sodium valproate, levetiracetam, phenytoin, and placebo).

Furthermore, compared with those treated with other antiepileptic drugs, patients treated with OXC had a comparable incidence of adverse events (RR =1.01, 95% CI: 0.92, 1.11; P=0.760).

https://www.mdlinx.com/neurology/medical-news-article/2017/03/07/epilepsy-children-oxcarbazepine-meta-analysis/7082510/?category=latest&page_id=1