Death by fentanyl?

By the time Cole Hartman arrived at Ronald Reagan UCLA Medical Center, he was in grave condition. The 8-year-old had gone into cardiac arrest after nearly drowning in a washing machine at his Castaic home. Paramedics had gotten his heart beating again, but he remained in a coma and on a ventilator.

Physicians at UCLA’s pediatric intensive care unit told Cole’s family that the child was not brain-dead but “would never recover normal neuro function and … could never awaken,” according to an entry in his medical chart.

The Hartmans decided to take Cole off life support and donate his organs. He was removed from the ventilator and, 23 minutes later with his family at his bedside, pronounced dead by an anesthesiologist.

The seemingly peaceful death four years ago is now the subject of an investigation by Los Angeles police and the district attorney’s office. Homicide detectives are looking into an allegation by a coroner’s investigator that the anesthesiologist gave Cole a fatal dose of the opioid fentanyl to hasten his death and increase the likelihood his organs could be harvested. No charges have been brought.

A lawyer for the anesthesiologist, Dr. Judith Brill, said the allegation was “factually wrong and patently offensive.”

Brill’s “only concern was to assure that this child, who had drowned and was never going to recover, would not suffer any pain following the removal of life support,” attorney Mark Werksman wrote in an email to The Times…

Detectives opened the case earlier this year. Denise Bertone, a veteran coroner’s investigator who specializes in child deaths, first flagged the use of fentanyl at the time of Cole’s 2013 autopsy and campaigned for years to persuade supervisors to reexamine the case. Her efforts resulted in the coroner’s office amending Cole’s death certificate in December to add fentanyl toxicity as a “significant cause” of his death.

“To me, this was not an academic question,” Bertone said in an interview.

Bertone filed a whistle-blower retaliation lawsuit last month accusing the coroner’s office of giving her less-desirable assignments as punishment for raising questions about Cole’s death…

Cole was born with fragile X syndrome, a genetic abnormality that causes intellectual and physical disabilities.

On July 31, 2013, his father came in from mowing the lawn and found Cole headfirst in a running washing machine, according to the coroner’s report and a recording of a 911 call. By his parents’ estimation, Cole’s head could have been underwater for as long as 25 minutes.

Cole was taken to a Santa Clarita hospital by ambulance and then flown by medical helicopter to UCLA later that night for more advanced care. In the pediatric intensive care unit, the Hartmans met Brill.

A professor emeritus of clinical anesthesiology and perioperative medicine at UCLA, Brill, 65, is a well-regarded expert in the treatment of seriously injured children. She helped write the state guidelines for pediatric critical care and spent much of her free time on medical missions to treat poor children in Africa, Asia and Latin America.

With other members of the medical team, she informed the Hartmans that a brain scan was “markedly abnormal” and suggested extensive damage from lack of oxygen, according to notes she made in Cole’s chart.

The family “unanimously stated that they would prefer to withdraw support” and subsequently decided to donate his organs, Brill wrote. 

Because Cole wasn’t brain-dead, the organ retrieval was to occur after the ventilator was removed and his heart stopped beating on its own under a procedure known as donation after cardiac death, or DCD. This type of donation began in the U.S. in the mid-1990s and has become increasingly common in the last decade as the medical community tries to meet the overwhelming need for organ donors. DCD accounted for about 10% of deceased donors last year.

DCD comes with time pressures. Organs can begin deteriorating immediately, and some are not suitable for transplantation after 30 minutes.

Cole was removed from the ventilator at 10:40 a.m. as a transplant team waited outside. He did not stop breathing immediately. What happened next is unclear. The full coroner’s report is sealed from public view pending the outcome of the police investigation, and UCLA declined to comment.

Bertone, who said she reviewed the full medical charts and autopsy records, alleged in her lawsuit that the boy “continued to gasp for air” and that Brill then gave him fentanyl “with the purpose of inducing his death.” Bertone’s suit and coroner’s records state that the administered dose was 500 micrograms…

In a portion of the chart reviewed by The Times, Brill does not mention fentanyl but wrote that “comfort care was provided throughout.” “Comfort care” is a term commonly used for the use of medications such as opioids or sedatives to ease pain, experts said.

Medical experts said it is difficult to know for sure whether patients such as Cole in vegetative states are experiencing pain, but physicians prefer to err on the side of caution when withdrawing life support.

“It’s generally thought you give enough medication to reassure everyone that the patient is comfortable, but not so much that it is actually the primary cause of death,” said anesthesiologist Nicholas Sadovnikoff, co-director of the surgical intensive care unit and co-chair of the ethics committee at Brigham and Women’s Hospital in Boston…

At the coroner’s office, Cole’s case was assigned to Bertone, the only full-time pediatric death investigator. A registered nurse, Bertone had investigated more than 2,500 cases, including numerous child abuse cases. Law enforcement officers across the county called on her frequently to interpret crime scenes and help interview distraught parents. Reviewing the medical records, Bertone said she had concerns about giving a boy who weighed 47 pounds that quantity of fentanyl.

Bertone told Dr. Mark Fajardo, then-chief medical examiner-coroner, she thought Cole died from fentanyl — making his death, in her estimation, a possible murder or manslaughter — and urged him to test a sample of the boy’s blood, she alleges in the lawsuit.

Fajardo declined and ruled the cause of death was near-drowning. Fragile X syndrome was listed as another significant cause, according to coroner’s records.

Bertone continued complaining to supervisors in person and in emails. Fajardo eventually ordered a blood test that showed fentanyl in Cole’s system. Bertone pressed him to change the cause of Cole’s death, but according to her lawsuit, Fajardo refused…

After Fajardo left office last year, Bertone approached the then-interim chief medical examiner, Dr. Lakshmanan Sathyavagiswaran, who agreed to reopen the case. A pediatric toxicologist brought in as an expert by the coroner’s office found that the fentanyl “was responsible for the death of this patient” and that the dose was “not consistent with a therapeutic dose for the management of pain and discomfort,” according to excerpts of his findings quoted in a coroner’s report.

As a result, Sathyavagiswaran changed Cole’s death certificate in December to add fentanyl toxicity to the list of causes of death and asked for a law enforcement investigation. The manner of death — whether it was an accident or a homicide — remains listed as “undetermined” pending the outcome of the investigation…

Bertone is no longer assigned full time to pediatric cases. In her lawsuit, she contends supervisors removed her from the work she loved in retaliation for challenging the handling of Cole’s case. She is suing the county for damages that include the loss of overtime, on-call pay and a take-home car…

Those who know Brill say she is deeply troubled by the accusations.

“This is someone who has really had an exemplary career,” said Dr. Jean Lake, a pediatric neurologist at Miller Children’s Hospital in Long Beach. She is “just so concerned that her ability, her skills, her intentions would be called into question.

http://www.latimes.com/local/lanow/la-me-adv-organ-donation-20170612-story.html

Courtesy of a colleague