McCrea M, Meier T, Huber D, Ptito A, Bigler E, Debert CT,
Manley G, Menon D, Chen JK, Wall R, Schneider KJ, McAllister T. Role of
advanced neuroimaging, fluid biomarkers and genetic testing in the assessment of
sport-related concussion: a systematic review. Br J Sports Med. 2017 Jun;51(12):919-929.
Abstract
OBJECTIVE:
To conduct a systematic review of published literature on
advanced neuroimaging, fluid biomarkers and genetic testing in the assessment
of sport-related concussion (SRC).
DATA SOURCES:
Computerised searches of Medline, PubMed, Cumulative Index
to Nursing and Allied Health Literature (CINAHL), PsycINFO, Scopus and Cochrane
Library from 1 January 2000 to 31 December 2016 were done. There were 3222
articles identified.
STUDY SELECTION:
In addition to medical subject heading terms, a study was
included if (1) published in English, (2) represented original research, (3)
involved human research, (4) pertained to SRC and (5) involved data from
neuroimaging, fluid biomarkers or genetic testing collected within 6 months of
injury. Ninety-eight studies qualified for review (76 neuroimaging, 16
biomarkers and 6 genetic testing).
DATA EXTRACTION:
Separate reviews were conducted for neuroimaging, biomarkers
and genetic testing. A standardised data extraction tool was used to document
study design, population, tests employed and key findings. Reviewers used a
modified quality assessment of studies of diagnostic accuracy studies (QUADAS-2)
tool to rate the risk of bias, and a modified Grading of Recommendations
Assessment, Development, and Evaluation (GRADE) system to rate the overall
level of evidence for each search.
DATA SYNTHESIS:
Results from the three respective reviews are compiled in
separate tables and an interpretive summary of the findings is provided.
CONCLUSIONS:
Advanced neuroimaging, fluid biomarkers and genetic testing
are important research tools, but require further validation to determine their
ultimate clinical utility in the evaluation of SRC. Future research efforts
should address current gaps that limit clinical translation. Ultimately,
research on neurobiological and genetic aspects of SRC is predicted to have
major translational significance to evidence-based approaches to clinical
management of SRC, much like applied clinical research has had over the past 20
years.
Courtesy of: https://www.mdlinx.com/neurology/medical-news-article/2017/06/21/advanced-neuroimaging-fluid-biomarkers-genetic-testing/7198138/?category=latest&page_id=2
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