Eivind Ystrom, Kristin Gustavson, Ragnhild Eek Brandlistuen,
Gun Peggy Knudsen, Per Magnus, Ezra Susser, George Davey Smith, Camilla
Stoltenberg, Pål Surén, Siri E. Håberg, Mady Hornig, W. Ian Lipkin, Hedvig
Nordeng, Ted Reichborn-Kjennerud. Prenatal
Exposure to Acetaminophen and Risk of ADHD. Pediatrics. Online ahead of print. http://pediatrics.aappublications.org/content/early/2017/10/26/peds.2016-3840
Abstract
OBJECTIVES: To estimate the association between maternal use
of acetaminophen during pregnancy and of
paternal use before pregnancy with attention-deficit/hyperactivity disorder
(ADHD) in offspring while adjusting for familial risk for ADHD and indications
of acetaminophen use.
METHODS: Diagnoses were obtained from the Norwegian Patient
Registry for 112 973 offspring from the Norwegian Mother and Child Cohort
Study, including 2246 with ADHD. We estimated hazard ratios (HRs) for an ADHD
diagnosis by using Cox proportional hazard models.
RESULTS: After adjusting for maternal use of acetaminophen
before pregnancy, familial risk for ADHD, and indications of acetaminophen use,
we observed a modest association between any prenatal maternal use of
acetaminophen in 1 (HR = 1.07; 95% confidence interval [CI] 0.96–1.19), 2 (HR =
1.22; 95% CI 1.07–1.38), and 3 trimesters (HR = 1.27; 95% CI 0.99–1.63). The HR
for more than 29 days of maternal acetaminophen use was 2.20 (95% CI
1.50–3.24). Use for <8 days was negatively associated with ADHD (HR = 0.90;
95% CI 0.81–1.00). Acetaminophen use for fever and infections for 22 to 28 days
was associated with ADHD (HR = 6.15; 95% CI 1.71–22.05). Paternal and maternal
use of acetaminophen were similarly associated with ADHD.
CONCLUSIONS: Short-term maternal use of acetaminophen during
pregnancy was negatively associated with ADHD in offspring. Long-term maternal
use of acetaminophen during pregnancy was substantially associated with ADHD
even after adjusting for indications of use, familial risk of ADHD, and other
potential confounders.
No comments:
Post a Comment