Forthun I, Wilcox AJ, Strandberg-Larsen K, Moster D, Nohr
EA, Lie RT, Surén P, Tollånes MC. Maternal Prepregnancy BMI and Risk of Cerebral
Palsy in Offspring. Pediatrics. 2016 Sep 8. [Epub ahead of print]
Abstract
OBJECTIVES:
To investigate the association between maternal
pre-pregnancy BMI and risk of cerebral palsy (CP) in offspring.
METHODS:
The study population consisted of 188 788 children in the
Mothers and Babies in Norway and Denmark CP study, using data from 2 population-based,
prospective birth cohorts: the Norwegian Mother and Child Cohort Study and the
Danish National Birth Cohort. Prepregnancy BMI was classified as underweight
(BMI <18.5), lower normal weight (BMI 18.5-22.9), upper normal weight (BMI
23.0-24.9), overweight (BMI 25.0-29.9), and obese (BMI ≥30). CP diagnoses were
obtained from the national CP registries. Associations between maternal
prepregnancy BMI and CP in offspring were investigated by using log-binomial
regression models.
RESULTS:
The 2 cohorts had 390 eligible cases of CP (2.1 per 1000
live-born children). Compared with mothers in the lower normal weight group,
mothers in the upper normal group had a 40% excess risk of having a child with
CP (relative risk [RR], 1.35; 95% confidence interval [CI], 1.03-1.78). Excess
risk was 60% (RR, 1.56; 95% CI, 1.21-2.01) for overweight mothers and 60% (RR,
1.55; 95% CI 1.11-2.18) for obese mothers. The risk of CP increased ∼4%
for each unit increase in BMI (RR, 1.04; 95% CI, 1.02-1.06). Estimates changed
little with adjustment for mother's occupational status, age, and smoking
habits.
CONCLUSIONS:
Higher prepregnancy maternal BMI was associated with
increased risk of CP in offspring.
Courtesy of Doximity
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