Nielsen NM, Munger KL, Koch-Henriksen N, Hougaard DM,
Magyari M, Jørgensen KT, Lundqvist M, Simonsen J, Jess T, Cohen A, Stenager E,
Ascherio A. Neonatal vitamin D status and risk of multiple sclerosis: A
population-based case-control study. Neurology. 2017 Jan 3;88(1):44-51.
Abstract
OBJECTIVE:
As previous research has suggested that exposure to vitamin
D insufficiency in utero may have relevance for the risk of multiple sclerosis
(MS), we aimed to examine the direct association between level of neonatal
vitamin D and risk of MS.
METHODS:
We carried out a matched case-control study. Dried blood
spots samples (DBSS) belonging to 521 patients with MS were identified in the
Danish Newborn Screening Biobank. For every patient with MS, 1-2 controls with
the same sex and birth date were retrieved from the Biobank (n = 972). Level of
25-hydroxyvitamin D (25[OH]D) in the DBSS was measured using liquid
chromatography tandem mass spectroscopy. The association between different
levels of 25(OH)D and risk of MS was evaluated by odds ratios (OR) calculated
in conditional logistic regression models.
RESULTS:
We observed that lower levels of 25(OH)D in neonates were
associated with an increased risk of MS. In the analysis by quintiles, MS risk
was highest among individuals in the bottom quintile (<20.7 nmol/L) and
lowest among those in the top quintile of 25(OH)D (≥48.9 nmol/L), with an OR
for top vs bottom of 0.53 (95% confidence interval [CI] 0.36-0.78). In the
analysis treating 25(OH)D as a continuous variable, a 25 nmol/L increase in
neonatal 25(OH)D resulted in a 30% reduced risk of MS (OR 0.70, 95% CI
0.57-0.84).
CONCLUSION:
Low concentrations of neonatal vitamin D are associated with
an increased risk of MS. In light of the high prevalence of vitamin D
insufficiency among pregnant women, our observation may have importance for
public health.
Editorial: Marrie RA,
Daumer M. A gestational dose of vitamin D per day keeps the MS doctor away. Neurology. 2017 Jan 3;88(1):13-14.
No comments:
Post a Comment