Krishna Prasad, Parag Barwad, Pruthvi,C.R, Krishna Santosh, JyothiVijay, SanjeevNaganur. Accelerated regression of cardiac rhabdomyoma by mTOR inhibitors in a neonate with heart failure: A case report. Indian Heart Journal, in press. https://doi.org/10.1016/j.ihjccr.2020.08.008
Abstract
Cardiac Rhabdomyomas (CR) are a rare occurrence with an
incidence of 0.1% and are the most common primary cardiac tumors in the fetus
and pediatric age groups. Although largely known as “spontaneously regressing
tumor” very rarely they cause symptoms of heart failure due to ventricular
dysfunction or outflow tract obstruction, or arrhythmias. When associated with
tuberous sclerosis complex (TSC) they are usually multiple in number. mTOR
inhibitors were recently approved by FDA for the treatment of TSC. We report a
case of fetal and neonatal rhabdomyoma presenting as heart failure refractory
to medical management and was treated with mTOR inhibitors (Everolimus) with
which the patient had improvement in symptoms and accelerated regression of
tumor. We conclude that rhabdomyomas though asymptomatic in most, can present
with refractory heart failure and mTOR inhibitors can be helpful in such cases.
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