Yan Y, Xie G, Zhou H, Liu H, Wan M. Altered spontaneous brain activity in patients with childhood absence epilepsy: associations with treatment effects. Neuroreport. 2020;31(8):613-618. doi:10.1097/WNR.0000000000001447
The study aims to detect resting-state functional MRI
(RS-fMRI) changes and their relationships with the clinical treatment effects
of anti-epileptic drugs (AEDs) for patients with childhood absence epilepsy
(CAE) using the fractional amplitude of low-frequency fluctuation (fALFF).
RS-fMRI data from 30 CAE patients were collected and compared with findings
from 30 healthy controls (HCs) with matched sex and age. Patients were treated
with first-line AEDs for 46.2 months before undergoing a second RS-fMRI scan.
fALFF data were processed using DPABI and SPM12 software. Compared with the
HCs, CAE patients at baseline showed increased fALFF in anterior cingulate
cortex, inferior parietal lobule, inferior frontal lobule, supplementary motor
area and reduced fALFF in putamen and thalamus. At follow-up, the fALFF showed
a clear rebound which indicated a normalization of spontaneous brain activities
in these regions. In addition, the fALFF changes within thalamus showed
significant positive correlation with the seizure frequency improvements. Our
results suggest that specific cortical and subcortical regions are involved in
seizure generation and the neurological impairments found in CAE children and
might shed new light about the AEDs effects on CAE patients.