Gipson TT, Poretti A, Kelley SA, Carson KA, Johnston MV,
Huisman TAGM. Characterization of the Basal Ganglia Using Diffusion Tensor
Imaging in Children with Self-Injurious Behavior and Tuberous Sclerosis Complex.
J Neuroimaging. 2019 May 6. doi: 10.1111/jon.12628. [Epub ahead of print]
Abstract
BACKGROUND AND PURPOSE:
Tuberous sclerosis complex (TSC) is a rare, genetic disease
that is associated with multiple manifestations including epilepsy and autism.
Self-injurious behaviors (SIBs) also occur in a subset of patients. This study
used diffusion tensor imaging (DTI) in children with TSC for quantitative and
volumetric analysis of brain regions that have been associated with SIB in
other genetic conditions.
METHODS:
We used DTI to compare 6 children with TSC-associated SIB
and 10 children with TSC without SIB. Atlas-based analysis of DTI data and
calculation of number of voxels; fractional anisotropy (FA); and mean, axial,
and radial diffusivity were performed for multiple regions; DTI measures were
summarized using medians and interquartile ranges and were compared using
Wilcoxon rank sum tests and false discovery rates (FDRs).
RESULTS:
Analysis showed that children with TSC and SIB had reduced
numbers of voxels (median) in the bilateral globus pallidus (right: 218 vs.
260, P = .008, FDR = .18; left: 222 vs. 274, P = .002, FDR = .12) and caudate
nucleus (right: 712 vs. 896, P = .01, FDR = .26; left: 702 vs. 921, P = .03,
FDR = .44) and reduced FA in the bilateral globus pallidus (right: .233 vs.
.272, P = .003, FDR = .12; left: .223 vs. .247, P = .004, FDR = .12) and left
caudate nucleus (.162 vs. .186, P = .03, FDR = .39) versus children without
SIB. No other statistically significant differences were found.
CONCLUSIONS:
These data support a correlation between lower volumes of
the globus pallidus and caudate with SIB in children with TSC.
Courtesy of: https://www.mdlinx.com/journal-summaries/tuberous-sclerosis-complex-diffusion-tensor-imaging/2019/05/07/7566165?spec=neurology
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