Yunjian Zhang, Yi Wang, Yuanfeng Zhou, Linmei Zhang, Lifei
Yu, Shuizhen Zhou. Therapeutic effects
of the ketogenic diet in children with Lennox-Gastaut syndrome. Epilepsy Research. In press.
Highlights
•The ketogenic diet can effectively control seizures in
children with LGS.
•The ketogenic diet can improve abnormal EEG background
activity and reduce IEDs.
•Early improved EEG background is a predictor of clinical
outcome in LGS.
Abstract
Objective
The aim of this study was to evaluate the efficacy of the
ketogenic diet (KD) on the clinical and electroencephalographic (EEG) features
of Lennox-Gastaut syndrome (LGS) and explore the relationships between EEG
changes and clinical efficacy.
Methods
We retrospectively studied 47 patients with LGS who accepted
KD therapy between May 2011 and May 2015. Clinical efficacy and EEG features
such as background activity, abnormal interictal epileptic discharges (IEDs)
and the discharge location were evaluated prior to and at 3 and 6 months after
therapy. Responders were defined as ≥50% seizure reduction.
Results
At 3 months of treatment, 23 patients (48.9%) had ≥50%
seizure reduction. Seven patients (14.9%) discontinued treatment between 3 and
6 months because of lack of efficacy or inability to adhere to the diet. At 6
months of treatment, 4 patients (10%) were seizure free, 5 (12.5%) had ≥90%
seizure reduction, 12 (30%) had a reduction of 50–89%, and 19 (47.5%) had
<50% reduction. Patients with improved EEG background and reduced IEDs had
an improved seizure reduction rate compared with patients without change in EEG
background or IEDs (p < 0.01).
Conclusions
The results show that the KD is effective in LGS. It can
control seizures and improve EEG abnormalities. Early improvement in the EEG
background and a reduction in IEDs may be predictors of a patient’s response to
diet.
Courtesy of: https://www.mdlinx.com/neurology/medical-news-article/2016/11/23/ketogenic-diet-lennox-gastaut-syndrome-eeg/6944241/?category=latest&page_id=1
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