Rom AL, Wu CS, Olsen J, Jawaheer D, Hetland ML, Christensen
J, Ottesen B, Mørch LS. Parental rheumatoid arthritis and childhood
epilepsy: A nationwide cohort study. Neurology. 2016 Nov 16. pii: 10.1212/WNL.0000000000003424.
[Epub ahead of print]
Abstract
OBJECTIVE:
To assess the influence of parental rheumatoid arthritis
(RA) on risk of epilepsy.
METHODS:
We performed a nationwide cohort study including all
singletons born in Denmark from 1977 to 2008 (n = 1,917,723) through individual
linkage to nationwide Danish registries. The children were followed for an
average of 16 years. Main outcome measures were adjusted hazard ratios (HRs)
for epilepsy with onset in early childhood (29 days-4 years), late childhood
(5-15 years), adolescence/adulthood (≥15 years), and at any age until the end
of follow-up (December 31, 2010).
RESULTS:
Compared to unexposed children, children exposed to maternal
RA had an increased risk of early and late childhood epilepsy (adjusted HRs
1.34 [95% confidence interval (CI) 1.13-1.60] and 1.26 [95% CI 1.13-1.41]),
while children exposed to maternal RA had no increased risk of epilepsy in
adolescence/adulthood (HR 1.15 [95% CI 0.92-1.45]). Paternal RA was not
associated with an overall risk of epilepsy in the offspring (HR 0.96 [95% CI
0.81-1.15]) or at any age. Children exposed to maternal RA in utero had a more
pronounced increased risk of early childhood epilepsy than children exposed to
mothers who were diagnosed with RA after childbirth (HR 1.90 [95% CI 1.26-2.86]
vs HR 1.26 [95% CI 1.03-1.52], respectively [p = 0.16]).
CONCLUSIONS:
Exposure to maternal RA was associated with an increased
risk of childhood epilepsy, while exposure to paternal RA was not, which
indicates that changes in the intrauterine environment may play a role.
No comments:
Post a Comment